The multistep synthesis of a hybrid material based on TiO2 core with an immobilized triazine-based copper(II)-NNN pincer complex is reported. The formation of the material was confirmed by FT-IR spectroscopy, elemental and thermogravimetric analysis, and the loading by copper ions was quantified by ICP/OES analysis. The properties of the hybrid material were further investigated by X-ray photoelectron spectroscopy (XPS), CW-ESR, UV-vis spectroscopy, and argon sorption. Efficient and regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles was achieved employing the hybrid material as catalyst in a mixture of H2O/EtOH as green solvent with an excellent catalytic activity with a TOF up to 495 h−1 at 50 °C. The reusability of the prepared hybrid material in the catalytic reaction was possible over five consecutive runs without significant loss of catalytic activity. The described method represents an effective …